【獲證專利公告】恭賀! 化學系林伯樵教授及團隊之研究成果「醣基定向之含醣多肽的修飾方法及其應用」獲得美國發明專利
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發明人 |
林伯樵教授 |
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系所 |
化學系 |
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專利名稱 |
醣基定向之含醣多肽的修飾方法及其應用 |
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證書號 |
US11780877B2 |
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公告日期 |
112年10月10日 |
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專利摘要 |
The present invention provides a method of sugar-guided modifying a glycosylated polypeptide. First, a boronic acid group of a probe molecule and a sugar group of the glycosylated polypeptide form a first covalent bond. Next, an alkyne group of a modifying group and an azide group of the probe molecule form a second covalent bond by adding a promoter. As a result, the modifying group can be close to the glycosylated polypeptide. Then, the modifying group can bind to a nucleophilic residue that is near the sugar group, through a nucleophilic addition reaction. The method of the present invention can selectively modify a given site with the guidance of the sugar group. |
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技轉服務窗口 |
卓妤芸小姐 Email：chosml@mail.nsysu.edu.tw(分機2627) 施宇翔先生Email：seanshih@mail.nsysu.edu.tw(分機2625) |
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