【獲證專利公告】恭賀! 化學系王家蓁教授及團隊之研究成果「提升紫外光發光二極體發光強度之方法及裝置」獲得美國發明專利!
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發明人 |
王家蓁教授 |
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系所 |
化學系 |
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專利名稱 |
提升血紅蛋白釋於氧氣至人體器官及周邊組織之方法及其醫藥組合物 |
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證書號 |
US10047063B2 |
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公告日期 |
107年8月14日 |
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專利摘要 |
A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes to organs or peripheral tissues in human bodies is disclosed by administering a compound of phthalides to a subject in need thereof. The compound of phthalides is characterized by a phthalide functional group which is represented as Formula I, and forms at least one hydrogen bond with αArg141 of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes, stabilizing the α1/α2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes in the low oxygen affinity “T” state and facilitating the oxygen release to the organs or the peripheral tissues. A medication for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin, or hemoglobin-based blood substitutes to organs or peripheral tissues in human bodies is also disclosed.
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技轉服務窗口 |
曾溫仁(分機2621) |
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