【獲證專利公告】恭賀!化學系王家蓁助理教授及團隊之研究成果「一種協助Hb-based血液代用品之氧氣釋放的方法」獲得美國發明專利!
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發明人 |
王家蓁助理教授 |
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系所 |
化學系 |
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專利名稱 |
一種協助Hb-based血液代用品之氧氣釋放的方法 |
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證書號 |
US9,713,602 B1 |
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公告日期 |
106年7月25日 |
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專利摘要 |
The present invention relates to a method for increasing the oxygen release efficiency of a hemoglobin-based blood substitute by using a phthalide compound, comprising the steps of: administering to a subject in need thereof the phthalide compound or co-administering to the subject in need thereof the phthalide compound along with the hemoglobin-based blood substitute, wherein the phthalide compound has an effect of increasing the oxygen release efficiency of the hemoglobin-based blood substitute, wherein the hemoglobin-based blood substitute can be fetal hemoglobin (HbF) or other Hb variants retaining two native .alpha. subunits. The phthalide compound is used to substitute for or cooperate with 2,3-BPG, to play a role of a 2,3-BPG substitute, to act on the hemoglobin-based blood substitute to effectively substitute the function of normal hemoglobin in releasing oxygen to tissue cells, in order to maintain the cellular oxygenation level within a normal range.
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技轉服務窗口 |
曾溫仁(分機2621) |
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